Document 0613
 DOCN  M9640613
 TI    Simultaneous development of two different B-cell lymphomas in a patient
       with acquired immune deficiency syndrome evidenced by molecular
       analysis.
 DT    9604
 AU    Dubus P; MacGrogan G; Vital C; Martin-Negrier ML; Morlat P; Ragnaud JM;
       de Mascarel A; Bloch B; Merlio JP; Department of Pathology, Centre
       Hospitalo-Universitaire de; Bordeaux, Universite de Bordeaux II, France.
 SO    Mod Pathol. 1995 Oct;8(8):825-9. Unique Identifier : AIDSLINE
       MED/96117031
 AB    We report a case of a man positive for the human immunodeficiency virus
       who rapidly died of lymphoma with cerebral, lung, and pericardic
       involvement. After autopsy, histopathological study of the different
       tumor sites showed the same morphological feature of immunoblastic
       lymphoma, with large areas of necrosis. In situ hybridization showed
       monotypic kappa light chain mRNA within lung lymphoma cells and
       monotypic lambda light chain mRNA within cerebral lymphoma cells.
       Polymerase chain reaction analysis showed two different immunoglobulin
       heavy chain gene rearrangements for lung and cerebral lymphoma. Here the
       simultaneous association of two malignant lymphomas derived from
       different B-cell clones indicates that molecular analysis of different
       tumor sites can distinguish between dissemination of the same lymphoma
       and simultaneous proliferation of different malignant B-cell clones.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/GENETICS/  PATHOLOGY
       Adult  Base Sequence  Brain Neoplasms/ETIOLOGY/GENETICS/PATHOLOGY  Case
       Report  Genotype  Human  Lung Neoplasms/ETIOLOGY/GENETICS/PATHOLOGY
       Lymphoma, B-Cell/*ETIOLOGY/GENETICS/PATHOLOGY  Male  Molecular Sequence
       Data  Neoplasms, Multiple Primary/*ETIOLOGY/GENETICS/PATHOLOGY  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

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